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Research Paper
Setting Up the Immune System: Perinatal Influences
by Annemarie Colbin, Ph.D.
PAPER FIRST PRESENTED AT THE THIRD
INTERNATIONAL DEAD SEA CONFERENCE, OCTOBER 20-24, 1996, IN ZICHRON
YAAKOV, ISRAEL. THE TITLE OF THE CONFERENCE WAS: “POTENTIATING
HEALTH AND THE CRISIS OF THE IMMUNE SYSTEM.” Published by Plenum
Press, NY-London, 1997.
1. ABSTRACT
The major factors influencing the development
of the immune system in the perinatal period include: the
parents’ health; the health, diet, drug and alcohol use of the
mother during pregnancy; the type of infant feeding at breast or
bottle; the child’s diet; and the use of antibiotics and
vaccines. This paper presents a brief overview of the role of
each of these influences, with some suggestions for maximizing
immune system health.
2. INTRODUCTION
There are two major definitions of the immune
system and its function. The best known states that its major
role is in distinguishing self from non-self. It is a function,
a system of communication between cells and organs. Immunologist
Steven B. Mizel, in his book In Self Defense, states
"Immune cells engage in something very much like conversation: an
elaborate network of announcements, commands, and
counter-commands. The placement, the timing, and the nature of
every signal is exquisitely precise; the effect of a single
command extremely powerful."
This conversation happens throughout the body, but most
particularly between the lymphatic system with its lymph nodes;
the blood stream with its white blood cells (lymphocytes), B and T
cells, and antibodies; the spleen, the thymus, the mucosal lining
of the respiratory system and the intestines, and possibly even
other organs made of lymphatic tissue such as the tonsils, the
adenoids, and the appendix.
Matzinger and Fuchs delineate a more
inclusive function of the immune system: its purpose is to
protect the individual from harm or danger. Their definition of
danger is "anything that causes cell stress or necrotic cell
death," as opposed to normal, programmed cell death. The danger
is sensed by the tissues themselves and communicated to the immune
system cells, which become activated as necessary
.
Human beings are born with a digestive
system, respiratory system, excretory system, and sensory
apparatus that are already working from birth on. These systems
cannot be forced to work; they either do or they don't. They
can be helped along with drugs, herbs, exercise, glasses, hearing
aids, and the like; but essentially the function of each organ
systems is inborn. It is the same with the immune system:
-
It is there from birth.
-
It cannot be forced to exist where it doesn't.
-
It can be helped along and allowed to flourish.
-
It can be disturbed, confused, inappropriately
challenged, or not given what it needs to develop.
A number of factors influence the immune
system both before and after birth. These factors are: the
parent's health; the mother's nutrition and lifestyle during
pregnancy (including the use of alcohol and pharmacological or
recreational drugs); breast-feeding or the lack of it; the
child's diet; and the use of antibiotics and vaccines.
3. DISCUSSION
Healthy parents provide the genetic material
to make a healthy child. During pregnancy, the developing fetus
can be affected by the pregnant woman's dietary and other health
habits. Alcohol use during pregnancy, which is usually associated
with poor nutritional status, may lead to the condition known as
fetal alcohol syndrome. This condition is characterized by
growth deficiencies, central nervous system disfunction, poor
coordination, hyperactivity, learning difficulties, and
developmental delays.
Both medical and recreational drugs can
affect the developing child's health. The most dramatic example
was Thalidomide, an anti-nausea drug given to pregnant women in
the Sixties; babies born to these women had deformed,
undeveloped, flipper-like arms. During the 40's and 50's, women
who appeared at risk for miscarriage were given DES
(Diethylstilbestrol), now no longer prescribed. The children of
those women, known as DES babies, developed cancer and other
illnesses of their reproductive organs in their adolescence and
young adulthood; others had a higher prevalence of autoimmune
diseases such as rheumatoid arthritis and pernicious anemia;
there were higher rates of unfavorable pregnancy outcomes and
psychiatric illnesses in DES daughters, and more testicular
cancer, infertility, and less heterosexual experiences in sons
.
The use of prescription drugs during
pregnancy has been studied extensively. As drugs invariably cross
the placenta,
they will affect the baby one way or another; however, there is
little general agreement about the seriousness or extent of the
damage, or even if any occurs. Some studies have found an
association between prescription and other drug use by pregnant
women and certain problems in their babies, such as birth defects
and musculoskeletal changes,
toxic effects on the heart,
and adverse effects on the brain and central nervous system.
Approximately 10% of birth defects are associated with exposure to
environmental substances including drugs.
See chart 1 for a list of medications that could cause birth
defects.
3.1. Breast Feeding
The most important of all perinatal variables
for a healthy immune system is breast feeding. In the first few
days, "before the milk comes in," the breasts secrete the highly
nutritious liquid known as colostrum. This substance clears the
mucus and meconium out of the baby's digestive system and sets up
the appropriate intestinal flora which protects the child against
digestive disorders. Colostrum contains the mother's immunity
factors, including immunoglobulins IgA and IgM,
which will protect the child against many varieties of
infections.
As the milk comes in, it brings immunity
factors that are specifically formulated for this mother's
infant. As she is exposed to the various toxins and pathogens
around her infant, as she holds, kisses, and nuzzles him, she
breathes in the air and particles around him; both her
milk-producing glands and her immune system then create the
specific antibodies needed by the baby, and these go through the
milk into the child.
Stored breast milk, however, is not as effective, as studies have
shown that its cellular components destabilize after heating, and
cannot tolerate either boiling or freezing.
Lawrence found that breast milk is protective
against the following virus and bacteria: poliovirus, E. coli,
staphylococci, Enterobacteriaceae, Candida albicans, Salmonella,
herpes virus, leukemia virus, influenza, and many others. In
addition, the breastfed infant's intestinal flora is composed
almost entirely of Lactobacillus bifidus, which inhibits
the growth of pathogenic bacteria. The bottle-fed infant's colon
one tenth of the bifido-bacteria, and more enterobacteria which is
associated with more illness.
Human milk has never been shown to cause
allergy, whereas cow's milk allergy is common. Among the symptoms
associated with these allergies we can count digestive distress
(colic, diarrhea, spitting up and vomiting, colitis), skin rashes,
runny noses, chronic cough and mucus, slow growth, and sudden
infant death. Sudden infant death is extremely rare among
breastfed infants.
Margaret K. Davis at the National Institute of Child Health and
Human Development, of the National Institutes of Health in
Bethesda, MD, found that infants bottle-fed or breast-fed for less
than six months had an increased risk for lymphoma and other
cancers. Her evidence suggested that breast fed infants are "less
severely affected by infections in infancy than are
artificially-fed infants. The type of infant feeding may affect
later obesity, cancer, and diabetes mellitus." The study
established that "human milk has substantial antimicrobial
effects;" therefore, "if human milk increases resistance to
infections in infancy, artificial feeding, which provides no
immunological benefits, may alter the child's responses to early
infection."
Essentially, mother's milk does two things
besides providing perfect nourishment: it provides immune
factors, and it doesn't make the child sick. Formula
allows for sickness also through two aspects: it provides no
immunities and it has the potential for actually causing illness
and allergies.
Breast feeding is best instituted immediately
after delivery. In order to maintain an abundance of milk, no
supplementary bottles or solids should be given to the baby for 6
months. Once solid foods are introduced, breast feeding can
continue for as long as mother and child want, in a gradually
decreasing manner.
3.2. Diet
Diet is an important variables for children's
health. Giving them natural, unprocessed foods is an essential
element for strengthening their immune system. Natural food
always has nutrients not yet discovered. In factory-processed
foods, the law allows a certain amount of rodent hairs, insect
fragments, and assorted other impurities considered harmless in
most canned or frozen foods.
For good nutrition and a strong immune
system, children need:
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Fresh, natural foods
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Vegetables (cooked and raw)
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Whole grains and breads
-
Protein foods: beans, fresh fish, naturally raised
fowl or meats
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Fruits, nuts and seeds
-
No milk products if the child is prone to
infections
3.3. Chemicals in the food
Chemicals in the food include pesticides,
herbicides, colorings, preservatives, and other additives.
Practically all the man-made pesticides used on our food supply
are known toxins, and have been associated with cancers,
birth defects, liver toxicity, peripheral and central neurological
problems, and reproductive problems in both animals and
humans.regulations
.
Because they eat more
food relative to their body size, children are in greater danger
from pesticides; the 1993 report of the National Academy of
Sciences, Pesticides in the Diets of Infants and Children,
states that low but steady exposure to pesticides early in life
can lead to a greater risk of cancer, neurological impairment, and
immune dysfunction.
Fruits and vegetables are most commonly
contaminated, but so are grains and meats, fish that have been
caught in polluted areas, as well as imported unregulated
produce. The NAS further states that exposure to common levels of
pesticides in available foods might be high enough for some
children to cause symptoms of acute pesticide poisoning.
The best way to avoid chemicals in the children's food is to
purchase only organic produce, grains, beans, nuts, and to buy
products from animals allowed to graze or run, fed natural
chemical-free food, and not given any antibiotics.
3.4. Antibiotics
Antibiotics, discovered by Alexander Fleming
in 1928, have been in widespread use since the mid-1940's. In
1957, Leo Schindel, MD, published a review of the medical
literature on the effects of thirteen different categories of
antibiotics, including penicillin, streptomycin, tetracyclines,
erythromycin, bacitracin, and polymyxin. He found a large number
of "unexpected reactions" duly described in the journals (see
chart 2).Schindel also points out that "most of the resistant
strains of staphylococci are to be found in hospitals, especially
in surgical and pediatric wards".
This review study is credible because it
dealt with studies made in the early days of antibiotic use,
shortly after World War II, and the adverse events could be
clearly noted in populations exposed to the drugs as compared to
those not exposed. Current studies would be more difficult to
evaluate, as antibiotic use is widespread throughout the world and
it is nearly impossible to find non-exposed individuals as
controls.
Antibiotics eradicate beneficial bacteria in
the intestines, including the bacteria that help synthesize
nutrients such as vitamin K, biotin, riboflavin, pyridoxine, and
folic acid. For that reason, frequent antibiotic use results in
vitamin deficiencies because of the inability of the intestines to
synthesize or absorb these nutrients. Amoxicyllin in particular
reduces drastically the numbers of the helpful bacteria, such as
the important lactobacillus types.
In chronic infections where they have been
used repeatedly with minimal success, the use of antibiotics is
questionable, if not damaging.
3.5. Vaccines
The immune system can also be damaged by
vaccinations, especially live and attenuated viral vaccines.
The Institute of Medicine in a 1994
publication, recognized 20 different possible adverse effects of
commonly administered vaccines; 11 of these are neurological
damage. Also recognized was the fact that there are not enough
studies in many cases to either establish or dismiss the vaccines
as being the cause of these common adverse effects
(See chart 3)
Live or attenuated viral vaccines can be
particularly dangerous, according to Professor Richard DeLong, a
retired microbiologist formerly of the University of Toledo and
Del Mar College, and author of Live Viral Vaccines: Biological
Pollution. (Live or attenuated viral vaccines include the
oral [Sabin] polio, measles, mumps, rubella, varicella [chicken
pox], influenza, and hepatitis A.) These vaccines can
- cause mutations
- cause chromosomal
aberrations
- cause birth defects
- cause cancer
- cause new diseases
- revert to virulence
- be contaminated with
other viruses and other microbes.
Professor DeLong theorizes that live viral
vaccines originate new diseases in four different ways (see chart
#4)
Other recognized adverse effects of vaccines
that relate to the immune system include swelling, redness,
induration, high fevers, inflammation, and immediate and
delayed-type hypersensitivities.,
Clearly, we need much more information on the
real effect of vaccines and antibiotics on the immune system of
children..
3.6.
Natural remedies
The childrens
immune system should be allowed to do exercise by recuperating
from minor illnesses on its own, with the help of soups, herbs,
and natural remedies, instead of being pushed and pulled by
pharmaceutical drugs, all of which have adverse effects. These
drugs are best left for serious illness and life or death matters
where the benefits outweigh the risks.
The following are essential to avoid the
occurrence of infections:
-
Good nutrition
-
Enough rest
-
Fresh air and exercise
-
No milk products
To manage minor illnesses, the following can
be used:
-
Natural home remedies (garlic, soups, teas, lemon, fasting)
-
Herbs
-
Homeopathy, naturopathy
-
Massage, chiropractic
Considering that chronic immune and autoimmune
diseases are a modern phenomenon, it is the author's
suggestion that more study is needed to ascertain their connection
with iatrogenic factors and bottle feeding.
4. SUMMARY
The basic needs for a healthy immune system
are: Healthy parents; nourishing food, no alcohol or drugs during
pregnancy; breast-feeding for at least six months. The immune
benefits of breast-feeding include: Colostrum colonizes the
intestinal flora for life; the mother's
own immunities are passed on; the mother continuously creates new
immune factors based on the environment; mother's
milk does not make children sick.
For good nutrition and a strong immune system,
children need fresh, natural foods: vegetables (cooked and raw),
whole grains and breads, protein foods (beans, fresh fish, naturally
raised fowl or meats), fruits, nuts and seeds, and no milk products
if the child is prone to infections.
Among the influences that damage the immune
system are
1) Chemicals in the food;
2) Antibiotics;
3) Vaccinations.
1. Chemicals in the food can cause cancers,
birth defects, liver toxicity, peripheral and central neurological
problems, reproductive problems in both animals and humans, and
immune malfunction.
2. Antibiotics damage the immune system
because they damage the intestinal flora, destroy beneficial
bacteria as well as harmful ones, and create resistance in
pathogenic bacteria.
3. Vaccines also damage the immune system.
There are numerous different possible adverse effects associated
with commonly administered vaccines, including anaphylaxis,
inflammation, immediate and delayed hypersensitivities, urticaria,
seizure disorder, brain damage, and death. There are not enough
studies in many cases to either establish or dismiss the vaccines as
being the cause of these common adverse effects. Live viral
vaccines can cause mutations, chromosomal aberrations, birth
defects, cause cancer, and new diseases. They can also revert to
virulence, and be contaminated with other viruses and other
microbes.
More study is needed to ascertain the role of
iatrogenicity in immune disorders.
----------------------------
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- Androgens (male
hormones),
- some antibiotics
(tetracycline, streptomycin, gentamicin, kanamycin, erythromycin
estolate, nalidixic acid, nitrofurantoin);
- some anticoagulant
drugs (dicumarol, warfarin);
- some antiepilepsy
drugs (Dilantin);
- benzodiazepines
(Valium, Librium);
- some thyroid drugs
(propylthiouracil, iodide, methimazole);
- tolbutamide; |
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- trimethadione (Tridione)
and paramethadione (Paradione);
- valproic acid (Depakene);
- corticosteroids
(including cortisone cream or ointments);
- diethylstilbestrol
(DES);
- isotretinoin (Accutane);
- lindane (Kwell);
- lithium;
- meprobamate (Miltown);
- podophyllin;
- thalidomide;
- alcohol,
- vitamin A,
- warfarin,
- hypoglycemics (i.e.,
insulin), |
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- non-steroidal
anti-inflammatory drugs (NSAIDs) (including aspirin and
ibuprofen).
- some cancer
chemotherapy drugs (methotrexate, aminopterin);
- chlorpropamide;
- estrogens,
- organic mercury
compounds,
- inhalational
anesthetics,
- live vaccines (such
as polio),
- penicillamine,
- progestogens,
- progesterone (high
doses),
- radiographic
contrast
materials (e.g.,
barium) |
Chart 1. Medications that can cause birth
defects
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CHART 3. LIST OF VACCINE ADVERSE EFFECTS,
INSTITUTE OF MEDICINE, USA, 1995
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- Encephalopathy
(acute and chronic)
- aseptic
meningitis
- subacute
sclerosing panencephalitis
- residual
(chronic) seizure disorder
- Guillain-Barré
syndrome (GBS)
- transverse
myelitis
- paralytic
poliomyelitis (in recipient or contact)
- myelitis
- neuropathy
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- optic neuritis
- sensorineural
deafness
- sterility via
orchitis
- anaphylaxis
(cessation of breathing)
- arthritis
- erythema
multiforme
-
insulin-dependent diabetes mellitus
- early
susceptibility to Hib disease
-
thrombocytopenia
- death |
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1) Gene recombination occurring among two or
more different viruses infecting the same cell;
2) Contaminating viruses in the live vaccine
from the cells that were used to produce the vaccine
3) Vaccine viruses changing their genes
during reproduction in the in vitro phase of vaccine
production
4) Vaccine viruses changing their genes
during in vivo reproduction in the vaccine recipient.
Richard DeLong,
Live Viral Vaccines: Biological Pollution. A Hearthstone Book,
Carlton Press Corp, New York, NY: 1996.
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CHART 4. HOW LIVE VIRAL VACCINE VIRUSES EFFECT
GENETIC CHANGES: Several Mechanisms
Chart 2. Unexpected reactions to antibiotics
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Allergic reactions:
- changes in the skin,
- contact dermatitis,
- "hairy" or "black"
tongue,
- development of fungi
in the mucous membranes,
- gastrointestinal
disturbances;
- inflammation of the
stomach and pharynx;
- urticaria,
- itching,
- herpes simplex,
- rosaceaform
dermatitis,
-purpura;
- acute fungus
infections of the skin;
- edema with swellings
of lips, eyes, mouth, tongue, or epiglottis; |
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- anaphylactic shock
- sudden death.
Specific organ reactions:
- Most frequent
allergic manifestations: Asthma and hay fever
- pulmonary symptoms,
- changes of the
blood, liver, veins, arteries;
- increased tendency
of the blood to clot faster than usual;
- narrowing of the
coronary arteries with subsequent heart damage (author's
emphasis);
- damage to the
kidneys; |
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- toxic reactions in
the central nervous system such as convulsions and coma;
- restlessness,
hallucinations, psychosis;
- endocarditis,
- infections of the
kidneys,
-pneumonia;
- infections of the
genital organs;
- staphylococcal
gastro-enterocolitis (a complication of tetracycline therapy),
which manifests as fever, nausea, vomiting, flatulence,
diarrhea, and collapse.
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Leo Schindel, MD, Unexpected reactions to
Modern Therapeutics: Antibiotics. (C. Thomas, Springfield,
IL: 1957)
5. REFERENCES
.
Mizel, Steven B., and Jaret, Peter, In Self Defense: The
Human Immune System -- the new frontier in medicine, p.7.
Harcourt Brace Jovanovich, New York: 1985.
2. Matzinger,
P; Fuchs, EJ, "Beyond Self and Non-Self: Immunity is a
conversation, not a war." The Journal of NIH Research,
July 1, 1996.
3. Lawrence,
Nutrition in Pregnancy and Lactation, p. 179.
4. Kenneth
L. Noller, MD, et al, "Increased occurrence of autoimmune
disease among women exposed in utero to diethylstilbestrol,"
Fertility and Sterility, Vol. 49, No. 6, June 1988, pp.
1080-82.
5. Meara,
J.; Fairweather, DV, "A randomized double-blind controlled trial
of the value of diethylstilboestrol therapy in pregnancy:
35-year follow-up of mothers and their offspring," British
Journal of Medicine, May 1989, 620-22.
6. Gerald G.
Briggs, Roger K. Freeman, Sumner J. Yaffe, Drugs in Pregnancy
and Lactation, Williams and Wilkins, Baltimore: 1986 ,
p. 140/d.
7.
Niebyl, Jennifer R., "Drugs and related areas in pregnancy,"
University of Iowa, College of Medicine, Department of
Obstetrics and Gynecology. Zent.bl. Gynakol. 113(1991)
375-388.
8. Lawson,
J.P., "Drug-induced lesions of the musculoskeletal system." Yale
University School of Medicine, New Haven, CT. Radiologic
Clinics of North America, March 1990; 28(2):233-46.
9. Balazs,
T., "Cardiotoxicity mechanisms from the point of view of
preclinical or premarketing safety evaluation." Archives of
Toxicology - Supplement, 1986; 9:171-7.
10. Redmond,
G.P., "Physiological changes during pregnancy and their
implications for pharmacological treatment." Clinical
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11.
Cope, Ian, "Medicines in Pregnancy," (letter). Chairman,
Working Party on the Categorisation of Drugs in Pregnancy,
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12. Lawrence,
Ruth A., MD, Breast-feeding: A Guide for the Medical
Profession. The C.V. Mosby Company, St. Louis: 1985, p.
127.
13. Marano,
Hara, "Breast or Bottle: New Evidence in an Old Debate," New
York Magazine, 6/29/1979..
15. Lawrence,
pp. 133-137.
16. Lawrence,
ibid., p. 138.
17. Davis,
M.K., Savitz, D.A., Graubard, B.I., "Infant feeding and
childhood cancer." The Lancet, 1988 August 13.
2(8607):365-368.
18. The
Food Defect Action Levels: Current Levels for Natural or
Unavoidable Defects for Human Use that Present No Health Hazard,
Department of Health and Human Services, Public Health Service,
FDA, Center for Food Safety and Applied Nutrition, Washington,
DC 20204: current through January 1989.
19. Colbin,
Annemarie, Food and Healing. Ballantine Books, NY:
1996.
20. Health
and Environment Digest, "Agricultural Health: Pesticides
and Cancer." A publication of the Freshwater Foundation, Volume
6, No. 5, September 1992.
21. Gray
Davidson, Osha, "Pesticides: The Killing Fields." Woman's
Day, September 20, 1994.
22. Lefferts,
Lisa Y., "A Commonsense Approach to Pesticides," Nutrition
Action Healthletter, September 1993. Center for Science in
the Public Interest, Washington, DC.
25. Schmidt,
Michael A., MD, Smith, Lendon H., MD, Sehnert, Keith W., MD,
Beyond Antibiotics: More Than 50 Ways to Boost Immunity and
Avoid Antibiotics, p. 55. North Atlantic Books, Berkeley,
CA: 1994.
26.
Adverse Events Associated with Childhood Vaccines: Evidence
Bearing on Causality, National Academy Press, Washington,
DC. 1994. Edited by Kathleen R. Stratton, Cynthia J. Howoe,
and Richard B. Johnston - sponsored by the Vaccine Safety
Committee of the Division of Health Promotion and Disease
Prevention, Institute of Medicine.
27. DeLong,
Richard, Live Viral Vaccines: Biological Pollution, p.
9. Carlton Press, NY: 1996.
28. "Diphtheria,
Tetanus, and Pertussis: Guidelines for Vaccine Prophylaxis and
Other Preventive Measures," a Recommendation of the Immunization
Practices Advisory Committee (ACIP). MMWR, Volume 34, No. 27,
July 12, 1985, p. 411.
19.
Physician's Desk Reference, 1995 edition.
30. Zand,
Janet; Walton, Rachel; Rountree, Bob, Smart Medicine for a
Healthier Child. Avery Publishing Group, New York, 1994.
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